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In addition, the Baltimore Longitudinal Study of Aging, a long-term follow-up study of an adult caucasian population, showed that IGT, and not impaired fasting glucose tolerance, elevates the risk of coronary heart disease [8]

Retatrutide induces greater body weight losses in obese mice than tirzepatide, due to an increased energy expenditure through GCGR activation 6

Experts believe that for heart failure and diabetic kidney disease, SGLT2is should come first

Compounded versions use the same active pharmaceutical ingredients but are prepared by compounding pharmacies under different regulatory frameworks

LillyDirect self-pay (Zepbound) Eli Lilly sells Zepbound directly to patients through its LillyDirect platform

How retatrutide compares to tirzepatide and semaglutide Direct head-to-head Phase 3 data between retatrutide, tirzepatide, and semaglutide does not exist yet (TRIUMPH-5 is the closest trial currently running in the diabetes population)